Research

Information from the world around us is first transmitted to our cerebral cortex via the primary sensory, or first-order, thalamic nuclei. Higher-order thalamic nuclei, like the pulvinar (PUL) and mediodorsal nucleus (MD), receive relatively little input from the sensory periphery and instead form pathways between cortical areas, which can strongly influence cortical activity from sensory to prefrontal cortex (PFC). These cortico-thalamo-cortical pathways are ideally positioned to regulate communication between cortical neurons.

Our vision is to establish the general principle across sensory, motor and cognitive domains that the higher-order thalamus helps transform and selectively route information across the cortex according to behavioral demands. Current evidence suggests key mechanisms involve the higher-order thalamus controlling the excitability and synchrony of cortical neurons.

To realize this vision, we combine three main methodological approaches:

  • Simultaneous multi-site neural recordings using electrode arrays in higher-order thalamic and cortical areas of behaving animals as a model for human cognition. This involves precise targeting of electrode arrays to interconnected network sites using neuroimaging techniques, particularly diffusion MRI, necessary because cortical areas project to circumscribed zones of higher-order thalamus
  • Manipulation of brain networks by mimicking endogenous neural dynamics, e.g., by simultaneously microstimulating across multiple contacts of electrode arrays, to control higher-order thalamus and its effect on the cortex and behavior
  • Intracranial neural recordings from epilepsy patients performing cognitive tasks

Current projects in our lab investigate thalamo-cortical interactions during:

The significance of this research is that it advances our understanding of fundamental cognitive processes, particularly how information is coded and flexibly transmitted in brain networks. Disruption of brain networks lies at the heart of many disorders, e.g., schizophrenia, Alzheimer’s disease and coma. Our research is an essential step towards effectively treating such disorders.